THE HUMAN ACHAETE-SCUTE-HOMOLOG-2 (ASCL2,HASH2) MAPS TO CHROMOSOME-11P15.5, CLOSE TO IGF2 AND IS EXPRESSED IN EXTRAVILLUS TROPHOBLASTS

Authors
ALDERS M HODGES M HADJANTONAKIS AK POSTMUS J VANWIJK I BLIEK J DEMEULEMEESTER M WESTERVELD A GUILLEMOT F OUDEJANS C LITTLE P MANNENS M
Citation
M. Alders et al., THE HUMAN ACHAETE-SCUTE-HOMOLOG-2 (ASCL2,HASH2) MAPS TO CHROMOSOME-11P15.5, CLOSE TO IGF2 AND IS EXPRESSED IN EXTRAVILLUS TROPHOBLASTS, Human molecular genetics, 6(6), 1997, pp. 859-867
Citations number
34
Categorie Soggetti
Genetics & Heredity",Biology
Journal title
Human molecular genetics → ACNP
ISSN journal
09646906
Volume
6
Issue
6
Year of publication
1997
Pages
859 - 867
Database
ISI
SICI code
0964-6906(1997)6:6<859:THA(MT>2.0.ZU;2-W
Abstract
Here we describe the cloning of the human Achaete Scute Homologue 2 (H ASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2) , a homologue of the Drosophila Achaete and Scute genes, In mouse, thi s gene is imprinted and maps to chromosome 7. We mapped the human homo logue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly c onserved in mouse and man, HASH2 is expressed in the extravillus troph oblasts of the developing placenta only, The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH 2 is also imprinted in man.