Enzymatic formation of 2,3-diaminopropionic acid, the direct precursor of the neurotoxin beta-ODAP, in Lathyrus sativus

Authors
Ikegami, F Yamamoto, A Kuo, YH Lambein, F
Citation
F. Ikegami et al., Enzymatic formation of 2,3-diaminopropionic acid, the direct precursor of the neurotoxin beta-ODAP, in Lathyrus sativus, BIOL PHAR B, 22(7), 1999, pp. 770-771
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
22
Issue
7
Year of publication
1999
Pages
770 - 771
Database
ISI
SICI code
0918-6158(199907)22:7<770:EFO2AT>2.0.ZU;2-R
Abstract
The enzymatic breakdown of beta-(isoxazolin-5-on-2-yl)-L-alanine (BIA) with formation of 2,3-diaminopropionic acid (DAPA), the direct precursor of the neurotoxin beta-ODAP in Lathyrus sativus, was confirmed in vitro, Some pro perties of the enzyme responsible for the biosynthesis of DAPA are describe d.