Automated system for capture and detection of nucleic acids

A fully automated nucleic acid analysis system is described, which offers p ositive sample identification, improved sensitivity and reduced user intera ction compared to conventional techniques. The system relies on the sequenc e-specific capture of DNA onto solid-phase particles, confirming product id entity without the problems of interpretation and lack of sequence informat ion inherent in gel-based analyses. The system can be used for sequence con firmation, mutation analysis and semiquantitative detection of PCR products .