Evaluation of antifungal activity of N-aryl-maleimides and N-phenylalkyl-3,4-dichloromaleimides

This study describes the antifungal activity of several N-aryl-maleimides a nd N-phenylalkyl-3,4-dichloromaleimides against pathogenic fungi by using d iffusion method. The results revealed that some compounds produced consider able inhibition zone halo, being more active than ketoconazole, used as a s tandard drug. The introduction of different substituent groups in the aroma tic ring caused a significant change in the activity. However, the introduc tion of two chlorine atoms in the imido double bond did not enhance the ant ifungal effects. These results are important, since some of these compounds may be used as models to obtain new and potent antifungal chemotherapeutic s.