Aa. Dahaba et al., Total intravenous anesthesia with remifentanil, propofol and cisatracuriumin end-stage renal failure, CAN J ANAES, 46(7), 1999, pp. 696-700
Citations number
10
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
Purpose: To compare recovery parameters of total intravenous anesthesia (TI
VA) with remifentanil and propofol, hemodynamic responses to perioperative
events, and pharmacodynamic parameters of cisatracurium in 22 end-stage ren
al failure and 22 normal renal function patients.
Methods: Anesthesia was induced with 2-3 mg.kg(-1) propofol and 1 mu g.kg(-
1) remifentanil and maintained with 75 mu g.kg(-1).min(-1) propofol and pro
pofol initial infusion of 0.2 mu g.kg(-1).min(-1) propofol. Arterial pressu
re and heart rate were maintained by remifentanil infusion rate adjustments
. The first twitch (TI) was maintained at 25% by an infusion-of cisatracuri
um.
Results: There was no difference in the time to maintenance of adequate res
piration, date of birth recollection, first analgesic administration, betwe
en the renal failure (4.8 +/- 2.5, 7.8 +/- 3.2, 12.3 +/- 5.3 min respective
ly) and the control group (5.2 +/- 2.8, 8.1 +/- 3.1, 12.7 +/- 5.5 min): nor
were there any differences in the time to 25% TI recovery, TI recovery fro
m 25% to 75%, or cisatracurium infusion rate between the renal failure grou
p (32.1 +/- 10.8 min, 18.2 +/- 5.5 min; 0.89 +/- 0.29 mu g.kg(-1).min(-1) r
espectively) and the control group (35.9 (7.9 min, 18.4 +/- 3.8 min, 0.95 /- 0.22 mu g.kg(-1).min(-1)).
Conclusion: End-stage renal failure does not prolong recovery from TIVA wit
h remifentanil and propofol, or the recovery from cisatracurium neuromuscul
ar block.