LYMPHOGRANULOMATOSIS - SYSTEMIC ANALYSIS OF AGE AND SEX CHARACTERISTICS OF HEMATOPOIESIS AND METABOLISM

72 clinical and laboratory features were analyzed on the IBM PC 486 fo r 126 new cases of lymphogranulomatosis prior to treatment. Myelograms were found to vary with sex and age of the patients demonstrating clo se relations between hemopoiesis and processes in the lymph nodes. In males maturation of myeloid elements KM was inhibited, though they had more monocytes KM. These monocytes got more numerous in unfavorable h istological variants and generalization. Lymphopenia and monocytosis w ere more pronounced in patients under 30 becoming more severe in gener alization and intoxication. Age-related changes in cholesterol in lymp hogranulomatosis patients were abnormal: in older patients cholesterol was low. This phenomenon is extremely unfavorable. The findings eluci date prognostic value of sex and age in lymphogranulomatosis and sugge st a hypothesis that monocytes (macrophages) and secreted by them mono kines are responsible for specific intoxication, neutrophilia and lymp hopenia. Berezovsky-Sternberg cells may be hybrids of macrophages and B-lymphocytes.