TOXIC COMPLICATIONS OF HIGH-DOSE POLYCHEM OTHERAPY IN TRANSPLANTATIONOF BONE-MARROW AND STEM-CELLS OF PERIPHERAL-BLOOD

The authors propose their own system of assessment of high-dose polych emotherapy toxicity. The system was applied to toxic complications of high-dose polychemotherapy in 31 patients with hematological malignanc ies subjected to allogenic, autologous bone marrow transplantation and transplantation of stem cells from peripheral blood within the scope of different protocols of high-dose polychemotherapy in conditioning r egimen. A special scale developed in tile Belarus center for bone marr ow transplantation basing on the above system provides prediction of s urvival in early posttransplantation period.