Molecular cloning and expression analysis of a novel human cDNA fragment encoding a putative Ser Thr protein kinase

A novel full-length cDNA encoding a putative serine/threonine kinase has be en isolated from a human testis cDNA library. A nucleotide sequence of 1225 bp length has been determined containing an open reading frame of 1044 nuc leotides (encoding 348 amino acids). In view of its degree of homology to m embers of the Ser/Thr protein kinase family and the closest relationship to Mus musculus STK-1, the predicted product was designated by the name of HU MSTK-1. Its mRNA is present in large amounts in thymus, and small amounts i n testis, small intestine and colon.