Jb. Brown et al., Ten-year follow-up of antidiabetic drug use, nonadherence, and mortality in a defined population with type 2 diabetes mellitus, CLIN THER, 21(6), 1999, pp. 1045-1057
Studies performed for drug registration provide little insight into the lon
g-term use and effectiveness of drugs in "real world" populations and setti
ngs. Tn obtain such insight, we used 10 years of electronic medical-record
data from Kaiser Permanente Northwest Division, a large, group-model health
maintenance organization in the United States, to study drug transitions,
lapses in drug therapy, and mortality among 693 persons with newly diagnose
d type 2 diabetes mellitus in 1988. We also studied an equivalently defined
cohort of 1071 persons with new diagnoses in 1994, for whom the availabili
ty of laboratory results via electronic data permitted additional analyses.
Cumulative mortality in the 1988 cohort increased steadily to 207 of 571 p
atients (36%) by 1997 (year 10). In 1988, 548 of 693 patients (79%) receive
d initial monotherapy with a sulfonylurea. Insulin use rose as the use of s
ulfonylureas declined. Over this period, 504 of 693 patients (73%) disconti
nued or added drug therapy. Eight percent to 10% of both sulfonylurea users
and insulin users discontinued drug use during the study period. In the 19
94 cohort, two thirds of the subjects who discontinued therapy and were tes
ted for glycosylated hemoglobin (Hb A(1c)) (n = 86) maintained good-to-exce
llent glycemic control. However, 78 discontinuers (38%) were not tested for
Hb A(1c), and, among this subset, 32% failed to visit a primary care clini
cian. The results of this study suggest that 5% to 10% of persons with type
2 diabetes mellitus avoid contact with the medical care system. Avoidance
persists for at least the first 10 years after diagnosis but is more common
in the first year after diagnosis. In addition, secondary failure of sulfo
nylureas begins within 1 year of diagnosis and continues at a steady pace.
Almost 80% of patients initially treated with sulfonylureas added or switch
ed to metformin or insulin within 10 years of diagnosis.