SERMs and Tibolone on breast tissue

Authors
Gompel, A Jacob, D de Chambine, S Mimoun, M Decroix, Y Rostene, W Poitout, P
Citation
A. Gompel et al., SERMs and Tibolone on breast tissue, CONTR FER S, 27(5), 1999, pp. 368-375
Citations number
25
Categorie Soggetti
Reproductive Medicine
Journal title
CONTRACEPTION FERTILITE SEXUALITE
ISSN journal
11651083 → ACNP
Volume
27
Issue
5
Year of publication
1999
Pages
368 - 375
Database
ISI
SICI code
1165-1083(199905)27:5<368:SATOBT>2.0.ZU;2-9
Abstract
SERMs are developped in HRT in order to provide the beneficial effects of e stradiol on bone and the cardiovascular system. SERMs are antiestrogens and their properties depend upon the pharmacological class they belong to. Tib olone is a progestin with mixed properties. Our studies on breast cells in vitro demonstrated that it behaves as a progestin in these cells. The clini cal data obtained with these various therapies on breast are presented.