Microbial transformations of cytotoxic natural products

The review describes the microbial transformations of different classes of cytotoxic natural products, i.e. terpenoids, steroids, alkaloids, quinones and other aromatics. The microbial transformations of cytotoxic sesquiterpe nes (nootkatone, aromodandrene, alloaromadendrene, 7 alpha-hydroxyfrullanol ide and parthenin), diterpenoids (aphidicolin, 2 alpha, 5 alpha, 10 beta, 1 4 beta-tetraacetoxy-4(20)-10-taxadiene, ent-15-oxobaur-16-en-19-oate, stemo din, sesquiterpene (sclareolide, alpha-santonin), triterpenoids (iridal, cu rcurbitacin E, 2-O-beta-D-glucopyranoside, sodic grindelate), steroids (wit haferin-A, 2,3 dihydro-3-methoxywithaferin-A), alkaloids (dihydrovindoline, vinblastine, leurosine, acronycin, tetrandirine, thelicarpine), aromatics (lapachol, chromanone, hydroxyflavones) and antibiotics (bleomycin, daunomy cin, olivomycin and viridicatumtoxin) are described.