Jf. De Celis et al., Regulation of the spalt/spalt-related gene complex and its function duringsensory organ development in the Drosophila thorax, DEVELOPMENT, 126(12), 1999, pp. 2653-2662
The nuclear proteins Spalt and Spalt-related belong to a conserved family o
f transcriptional regulators characterised by the presence of double zinc-f
inger domains, In the wing, they are regulated by the secreted protein Deca
pentaplegic and participate in the positioning of the wing veins. Here, we
identify regulatory regions in the spalt/spalt-related gene complex that di
rect expression in the wing disc. The regulatory sequences are organised in
independent modules, each of them responsible for expression in particular
domains of the wing imaginal disc, In the thorax, spalt and spalt-related
are expressed in a restricted domain that includes most proneural clusters
of the developing sensory organs in the notum, and are regulated by the sig
nalling molecules Wingless, Decapentaplegic and Hedgehog, We find that spal
t/spalt-related participate in the development of sensory organs in the tho
rax, mainly in the positioning of specific proneural clusters. Later, the e
xpression of at least spalt is eliminated from the sensory organ precursor
cells and this is a requisite for the differentiation of these cells. We po
stulate that spalt and spalt-related belong to a category of transcriptiona
l regulators that subdivide the thorax into expression domains (prepattern)
required for the localised activation of proneural genes.