Many studies have shown that loss of endothelium-derived nitric oxide is a
major factor of ischemic episodes in patients with coronary artery disease
and there is increasing evidence to suggest that nitric oxide might exert a
ntiatherosclerotic actions. Based on these concepts, the results of animal
studies on the effects of lipid lowering drugs, antioxidants, angiotensin c
onverting enzyme inhibitors, Ca2+ channel blockers, estrogens and agents wh
ich modulate nitric oxide bioavailability are presented and compared to the
results of patient studies and clinical trials. In spite of encouraging re
sults obtained with antioxidants in animals, clinical trials could only sho
w a clear positive effect of vitamin E treatment on the outcome of cardiova
scular disease. Angiotensin converting enzyme inhibitors can ameliorate end
othelial dysfunction in coronary heart disease, but their impact on disease
progression remains unclear. There is evidence that estrogen replacement t
herapy in post-menopausal women may increase the bioavailability of nitric
oxide. Finally, improved endothelial function and plaque stability clearly
contribute to the clinical benefits of Lipid lowering interventions, statin
s in particular. Taken together, these studies lend support to the concept
that improving endothelial function and nitric oxide release might serve as
valuable elements in the prevention or therapy of cardiovascular disease.
(C) 1999 Elsevier Science B.V. All rights reserved.