Autoimmune cholangitis: Case report

We report on 2 patients who showed mixed signs of primary biliary cirrhosis and autoimmune hepatitis. Both patients were female, in their fifties (54 and 58), their laboratory tests indicated cholestasis, and a liver biopsy r evealed liver cirrhosis with significant lesions of the bile ducts. Both we re treated with prednisolone with their liver tests showing a rapid normali zation of their aminotransferases. These patients can be considered as pres enting with what is known as the overlap syndrome or autoimmune cholangitis , which has the clinical, biochemical, immunological, and histopathological characteristics of primary biliary cirrhosis and autoimmune hepatitis type I.