The expression of basic fibroblast growth factor (bFGF) in tumor-associated stromal cells and vessels is inversely correlated with non-small cell lung cancer progression

Tumor progression results from complex interactions between tumor and tumor -associated host tissue. Basic fibroblast growth factor (bFGF), via activat ion of its receptor, FGFR-1, has been postulated to be an important inducer of host stromal response and angiogenesis. To assess the putative role of tumor-associated stromal cells and vessels in tumor progression, we studied non-small cell lung cancer (NSCLC) from 84 patients, including 51 squamous cell carcinomas and 33 nonsquamous cell carcinomas, by immunohistochemical detection. bFGF and FGFR-1 immunoreactivity was observed in tumor and in t umor-associated stromal cells and vessels. The expression of bFGF and FGFR- 1 in stromal cells was higher in squamous than in non-squamous cell carcino mas (respectively, P = .007 and P = .0004). We found that bFGF and FGFR-1 e xpression in tumor and tumor-associated stromal cells and vessels was direc tly correlated with host stromal response, as assessed by intratumoral exte nsion of stroma, but not with angiogenic response, as assessed by microvess el count. Although FGFR-1 expression of tumor cells was directly correlated with T-stage (P = .03), bFGF expressions of tumor-associated stromal cells and vessels were inversely correlated with lymph node metastasis (respecti vely, P = .0001 and P = .0002) and advanced pathological stage (respectivel y, P = .03 and P = .01). These findings suggest that bFGF might mediate hos t stromal response in NSCLC and that the expression of bFGF in tumor-associ ated stromal cells and vessels might have an inhibitory role in NSCLC progr ession. Copyright (C) 1999 by W.B. Saunders Company.