Registration of stereo and temporal images of the retina

The registration of retinal images is required to facilitate the study of t he optic nerve head and the retina. The method we propose combines the use of mutual information as the similarity measure and simulated annealing as the search technique. It is robust toward large transformations between the images and significant changes in light intensity. By using a pyramid samp ling approach combined with simulated reannealing we find that registration can be achieved to predetermined precision, subject to choice of interpola tion and the constraint of time. The algorithm was tested on 49 pairs of st ereo images. and 48 pairs of temporal images with success.