A Compton camera is being tested for nuclear medicine applications. Our des
ign uses a single 3 cm by 3 cm silicon pad detector as the first detector s
ystem, and SPRINT, an array of position-sensitive sodium iodide modules, as
the second detector. Experimental results with a Tc-99m point source show
coincidence energy spectra agreeing with theoretical predictions. The coinc
idence energy spectra for both silicon and SPRINT detectors correspond to t
he geometry-determined scattering angle range. Recorded energy falls outsid
e of strict geometric limits because of Doppler broadening and detector ene
rgy resolution effects. The summed energy peak in the initial data run for
a Tc-99m source has a FWHM energy resolution of 33 keV, primarily due to en
ergy uncertainty in the SPRINT modules. A second data run showed an improve
ment to 25 keV in summed energy resolution due to careful calibration of, a
nd correction for, significant first and second detector gain nonuniformiti
es. Images generated from the second acquired data set result in a backproj
ection image resolution of 1.5 cm at a source distance of 10 cm. Analytical
and Monte Carlo calculations show a very close agreement of 1.6 cm. Using
a list-mode maximum likelihood EM reconstruction algorithm, the image resol
ution is improved to 7 mm, although the resolution recovery is at the expen
se of increased noise in the image.