Somatic transgenesis and DNA immunization - Rational alternatives

DNA vaccination has opened up new avenues in vaccine development. In this a rticle, Maurizio Zanetti and colleagues discuss their approach to develop s omatic transgene immunization in which natural infection is mimicked by usi ng transgenes under the control of lymphoid tissue-specific regulatory elem ents. Thus, the immune system plays a more integrated role in the immunizat ion process.