No evidence for an involvement of alleles of polymorphisms in the serotonin(1D beta and 7) receptor genes in obesity, underweight or anorexia nervosa

Authors
Hinney, A Herrmann, H Lohr, T Rosenkranz, K Ziegler, A Lehmkuhl, G Poustka, F Schmidt, MH Mayer, H Siegfried, W Remschmidt, H Hebebrand, J
Citation
A. Hinney et al., No evidence for an involvement of alleles of polymorphisms in the serotonin(1D beta and 7) receptor genes in obesity, underweight or anorexia nervosa, INT J OBES, 23(7), 1999, pp. 760-763
Citations number
28
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
INTERNATIONAL JOURNAL OF OBESITY
ISSN journal
03070565 → ACNP
Volume
23
Issue
7
Year of publication
1999
Pages
760 - 763
Database
ISI
SICI code
0307-0565(199907)23:7<760:NEFAIO>2.0.ZU;2-E
Abstract
The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here w e describe the screening of the known Phe-124-Cys polymorphism in the 5-HT1 D beta receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT7 receptor gene. For association tests allele frequencies were compared betw een up to 393 extremely obese children and adolescents, 142 underweight stu dents and 84 patients with AN. None of the association tests revealed nomin al P-values below 0.3. We conclude that a major role of the investigated po lymorphisms in body weight regulation or AN appears unlikely.