Spatio-temporal analysis of electric brain activity during semantic and phonological word processing

There is an ongoing debate in cognitive neuroscience about the time course and the functional independence of the different processes involved in enco ding written language material. New data indicate very fast and highly para llel language analysis networks in the brain. Here we demonstrate a methodo logical approach to study the temporal dynamics of this network by searchin g for time periods where different task demands emphasize different aspects of the network. Multi-channel event related potentials (ERPs) were recorde d during a semantic and a phonological reading task from 14 healthy subject s. Signals were analyzed exclusively on the basis of the spatial configurat ion of the electric potential distributions (ERP maps), since differences i n these spatial patterns directly reflect changes in the configuration of t he active sources in the brain. This analysis did not reveal any difference s of the evoked brain electric fields between the two tasks up to 280 ms po st-stimulus. The ERP maps then differed for a brief period between 280 and 380 ms, before they were similar again. The analysis of the maps using a gl obal linear localization procedure revealed a network of areas, active in b oth tasks, that mainly involved the left postero-temporal and left antero-t emporal regions. The left posterior activation was found already around 100 ms post-stimulus, indicating that language-specific functions appear early in time. We therefore conclude that phonological and semantic processing a re essentially performed in both tasks and that only late decision-related processes influence the relative strength of activity of the different modu les in the complex language network. (C) 1999 Elsevier Science B.V. All rig hts reserved.