Comparative study of the in vitro antifungal activity of bifonazole, naftifine and sertaconazole against yeasts

The in vitro activity of three antifungal agents was tested and compared ag ainst 151 yeast strains, including ten Candida species, Cryptococcus neofor mans, Rhodotorula rubra, and Trichosporon cutaneum, Minimum inhibitory conc entrations (MICs) were determined by a microdilution technique in Shadomy m odified liquid medium. The mean MICs of sertaconazole (0.34 mg/L) were lowe r than those of naftifine (16.3 mg/L) and bifonazole (13.2 mg/L). These res ults suggest that sertaconazole is more active against Candida spp than oth er topical agents such as bifonazole and naftifine.