Associations between cognitive impairment and tardive dyskinesia: Another perspective

The extended administration of neuroleptics, especially those of high poten cy, is the essential etiologic factor in the development of tardive dyskine sia (TD). Schizophrenic patients, almost all of whom receive neuroleptics t o reduce psychotic symptoms, are therefore at risk for the development of T D Tn this review of the literature, we propose that neuroleptic use is not the sole risk factor for the emergence of TD. Rather, we attempt to demonst rate that impairments of cognitive function play a role in the development of TD. Furthermore, we show that this idea has explanatory value for unders tanding higher rates of TD in the elderly.