Ar. Katritzky et al., Preparation of polymer-bound 1H-benzotriazole, a new potential scaffold for the compilation of organic molecule libraries, J COMB CHEM, 1(2), 1999, pp. 173-176
An efficient method for the preparation of polymer-bound 1H-benzotriazole h
as been devised. The reaction of Merrifield resin with sodium 3-nitro-4-ami
nophenolate and the subsequent reduction and reaction with isoamyl nitrite
afforded benzotriazole preloaded resin. A series of tertiary amines and a t
osylamide were prepared using solid-phase benzotriatole-mediated transforma
tions.