Single-bead fluorescence microspectroscopy: Detection of self-quenching influorescence-labeled resin beads

Authors
Yan, B Martin, PC Lee, J
Citation
B. Yan et al., Single-bead fluorescence microspectroscopy: Detection of self-quenching influorescence-labeled resin beads, J COMB CHEM, 1(1), 1999, pp. 78-81
Citations number
26
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF COMBINATORIAL CHEMISTRY
ISSN journal
15204766 → ACNP
Volume
1
Issue
1
Year of publication
1999
Pages
78 - 81
Database
ISI
SICI code
1520-4766(199901)1:1<78:SFMDOS>2.0.ZU;2-Q
Abstract
We have characterized two sets of fluorescence-labeled beads with single-be ad fluorescence microspectroscopy. Our results demonstrate the possible sel f-quenching effect on the fluorescence in the resin bead and, therefore, ca ll for a careful selection of fluorophores and a rigorous control of the la beling reaction yield in order to generate labeled beads for combinatorial chemistry and other disciplines.