Chemistry of fluorinated vinamidinium salts: novel reactions of beta-trifluoromethyl vinamidinium salt with Grignard reagents

Authors
Yamanaka, H Uegaki, T Ishihara, T Kubota, T Gupton, JT
Citation
H. Yamanaka et al., Chemistry of fluorinated vinamidinium salts: novel reactions of beta-trifluoromethyl vinamidinium salt with Grignard reagents, J FLUORINE, 97(1-2), 1999, pp. 101-108
Citations number
41
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
97
Issue
1-2
Year of publication
1999
Pages
101 - 108
Database
ISI
SICI code
0022-1139(19990720)97:1-2<101:COFVSN>2.0.ZU;2-U
Abstract
beta-Trifluoromethyl vinamidinium salt 1 reacted cleanly with a variety of Grignard reagents 2 in tetrahydrofuran under reflux for 3 h to produce a mi xture of diastereoisomers (dl and meso) of the corresponding difluoromethyl ene compounds 3 in good to excellent yields. (C) 1999 Elsevier Science S.A. All rights reserved.