Cyclization of 2-and 3-indolylthiobenzoic, phenylacetic and nicotinic acids and esters to novel indole-containing tetracyclic ring systems.

Citation
P. Hamel et al., Cyclization of 2-and 3-indolylthiobenzoic, phenylacetic and nicotinic acids and esters to novel indole-containing tetracyclic ring systems., J HETERO CH, 36(3), 1999, pp. 643-652
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
36
Issue
3
Year of publication
1999
Pages
643 - 652
Database
ISI
SICI code
0022-152X(199905/06)36:3<643:CO23PA>2.0.ZU;2-G
Abstract
A series of 2- and 3-indolylthio benzoic, phenylacetic and nicotinic acids or esters were cyclized under dehydrative conditions affording several tetr acyclic indole-containing ketones, several of which constitute the first re ported examples of novel ring systems, such as the [1]benzothiepino[2,3-b] and [3,2-b]indole and the pyrido[3'2':5,6] and [3'4':5,6]thiopyrano[2,3-b] and [3,2-b]indole as well as the [3'2':5,6] and [3'4':5,6][1,3]thiazino[3,2 -a]indole ring systems.