S. Gurel et al., The relationship between c-erbB-2 oncogene expression and clinicopathological factors in gastric cancer, J INT MED R, 27(2), 1999, pp. 74-78
Citations number
11
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Gastric carcinoma is one of the most common carcinomas and a leading cause
of death from cancer in Turkey. The relationship between clinicopathologica
l features of the disease and oncogenes is under investigation. In this ret
rospective study we investigated the relationships between expression of c-
erbB-2 oncoprotein and grade, stage and pathological characteristics of the
tumour, and prognosis. Formalin-fixed, paraffin-embedded tissue sections w
ere prepared from gastrectomy specimens from 55 patients with gastric carci
noma. The tissue sections were stained immunohistochemically to reveal c-er
bB-2 protein. Six (10%) of the tumours stained positively for c-erbB-2 prot
ein. There was no statistically significant association (P > 0.5) between c
-erbB-2 staining and tumour grade, stage or pathological characteristics (n
ecrosis, lymph-node infiltration), or between staining and prognosis. The r
esults suggest that overexpression of c-erb-B-2 protein is not related to t
he pathological characteristics of the tumour in gastric carcinoma and is n
ot an important prognostic indicator.