Expression of p53 protein and prognosis in gastric carcinoma

A study was carried out to assess whether p53 expression is related to tumo ur type, grade or pathological characteristics, or to prognosis, in gastric cancer. Immunohistochemical studies were performed to detect p53 protein i n sections from 55 consecutive gastrectomy or partial gastrectomy specimens . Tumours were classified for T-stage, histopathological grade and patholog ical characteristics. Immunohistochemical staining detected p53 protein in 11 (19%) of the 55 specimens. There was no statistically significant differ ence between patients with p53 positively staining tumours and patients wit h p53 negatively staining tumours with regard to tumour grade, stage or pat hological characteristics (lymph-node infiltration, depth of invasion, necr osis, or necrosis of vessels). Survival time was statistically significantl y lower in patients with positively staining tumours (mean survival times 1 2.0 and 23.4 months, respectively). These results suggest that expression o f p53 protein is related to poor prognosis in gastric carcinoma.