Allergic dermatitis due to oral ebrotidine

We report the case of a woman who developed generalized dermatitis after 1 week of treatment with ebrotidine, a new H-2-receptor antagonist taken to p revent gastroduodenal lesions caused by nonsteroidal inflammatory drugs. Pa tch tests with ebrotidine and other H-2-receptor antagonists ranitidine, ci metidine and famotidine were negative. Oral challenge test with ebrotidine showed the development of lesions similar to those appearing previously. Or al challenge test with ranitidine and cimetidine were negative, possibly du e to the difference in the side chain chemical structure of ebrotidine and other H-2-receptor antagonists. This is the first reported case of allergic dermatitis caused by ebrotidine.