C. Vadasz et al., SELF-ADMINISTRATION OF ETHANOL - TOWARDS THE LOCATION OF PREDISPOSINGPOLYGENES IN QUASI-CONGENIC ANIMAL-MODELS, Alcohol, 13(6), 1996, pp. 617-620
Alcohol consumption by C57BL/6By background and BALB/cJ donor strains,
and by two recently developed quasi-congenic QTL-introgression strain
s, which share about 96% of their genes with the background strain, wa
s studied in a limited access paradigm. Alcohol and water were offered
for 60 min per day using modified pipettes on a drinking cage. Increa
sing concentrations of alcohol solutions, 3, 6, and 12%, were given fo
r days 1-7, 8-14, and 15-22, respectively. Consumption of the 12% alco
hol solution was highest in C57BL/6By (0.72 g/kg/h), lowest in BALB/cJ
(0.14 g/kg/h). The B6.Cb(4)i(5) beta 13 quasi-congenic strain, in spi
te of its genetic similarity to the C57BL/6By background strain, consu
med significantly less alcohol (0.41 g/kg/h) than the background strai
n. The results suggest that polygenes that reduce alcohol consumption
were introgressed from the BALB/cJ donor strain into the C57BL/6By bac
kground strain, and that the b(4)i(5) series of the B6.C quasi-congeni
c QTL-introgression strains may be useful in mapping genes that influe
nce alcohol-related behaviors. Locations of the introgressed candidate
polygenes were tentatively identified by analyzing microsatellite map
s of two of the quasi-congenic strains. Copyright (C) 1996 Elsevier Sc
ience Inc.