Low prevalence of clinicopathologic and sialographic changes in salivary glands of men with Sjogren's syndrome

Sjogren's syndrome (SS) is uncommon in men and there are few reports that d escribe their clinical features. In the present study, we investigated sali vary gland manifestations in men with SS and compared the results with thos e in women patients. This study included 12 men and 117 women with SS, and the mean stimulated parotid flow rate in men (4.1 ml/5 min, n=10) was highe r than that-df the women (3.1 ml/5 min, n=101). The prevalence of SS-relate d sialographic findings, such as globular and punctate sialectasis, was sig nificantly (P<0.05) lower in men (3/11) than in women (72/117). The prevale nce of grade 4 cases on labial salivary gland biopsy was also significantly (P<0.01) lower in men (4/11) than in women (82/111). These results indicat e a lower prevalence of SS;related clinicopathologic and sialographic chang es in men with SS than in women with the same condition.