Genetic aberrations in oligodendroglial tumours: An analysis using comparative genomic hybridization (CGH)

Four low-grade oligodendrogliomas, nine anaplastic oligodendrogliomas and t wo mixed oligoastrocytomas were investigated for chromosomal aberrations by comparative genomic hybridization on formalin-fixed, paraffin-embedded tis sue samples, The most frequent losses observed involved Ip, 9p, 10pq, 14q, 16p, 19q, while the most frequent gains were seen on 7pq, 11pq, 17p, 19pq, and Xp. In one oligodendroglioma, a highly specific amplification of 1q32.1 was seen. The frequent losses of 14q have not been reported previously. Zn the two cases of mixed oligoastrocytomas multiple gains and losses were fo und that did not show a clear overlap with the alterations found in the pur e oligodendrogliomas. Copyright (C) 1999 John Wiley & Sons, Ltd.