Gl. Bremer et al., P53 TUMOR-SUPPRESSOR GENE PROTEIN EXPRESSION IN CERVICAL-CANCER - RELATIONSHIP TO PROGNOSIS, European journal of obstetrics, gynecology, and reproductive biology, 63(1), 1995, pp. 55-59
Objective: Mutation of the p53 gene can be found in several human tumo
rs. We tested the hypothesis whether overexpression of p53 protein is
a parameter of more aggressive disease in patients with cervical cance
r. Study design: In this study, we describe the effects of p53 overexp
ression in 150 patients with cervical cancer (Figo stage IB-IV) by ass
essing expression patterns of the p53 gene product using a monoclonal
anti-p53 antibody (D07). Results: Overexpression of p53 tumor suppress
or gene protein was observed in 30.2%, of the tumors, low expression i
n 30.7% and 39.1% of the tumors showed no p53 immunoreactivity. With i
ncrease in stage, p53 overexpression raised from 20.1% in stage IB ro
60% in stage IV. A significant correlation between p53 overexpression
and disease-free survival of patients was observed, however, after str
atification for stage, this effect disappeared. Conclusions: The p53 m
utation expressed as p53 tumor suppressor gene protein overexpression
is a late event in cervical cancer genesis and does not appear to be o
f prognostic significance in cervical cancer.