Resistance of ribosomal protein mRNA translation to protein synthesis shutoff induced by poliovirus

Poliovirus infection induces an overall inhibition of host protein synthesi s, although some mRNAs continue to be translated, suggesting different tran slation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of riboso mal protein SG is involved in the regulation. Here, we report that the tran slation of ribosomal protein mRNAs resists poliovirus infection and correla tes with an increase in p70(s6k) activity and phosphorylation of ribosomal protein S6.