Interaction of human immunodeficiency virus-derived vectors with wild-typevirus in transduced cells

Authors
Bukovsky, AA Song, JP Naldini, L
Citation
Aa. Bukovsky et al., Interaction of human immunodeficiency virus-derived vectors with wild-typevirus in transduced cells, J VIROLOGY, 73(8), 1999, pp. 7087-7092
Citations number
30
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
8
Year of publication
1999
Pages
7087 - 7092
Database
ISI
SICI code
0022-538X(199908)73:8<7087:IOHIVV>2.0.ZU;2-J
Abstract
The interaction of human immunodeficiency virus (HIV)-derived vectors with wild-type virus was analyzed in transduced cells. Vector transcripts upregu lated by infection had no measurable effect on HIV type 1 (HIV-1) expressio n but competed efficiently for encapsidation, inhibiting the infectivity an d spread of HIV-1 in culture and leading to mobilization and recombination of the vector. These effects were abrogated with a self-inactivating vector .