A survey of clinical used drugs in PVR

Colchicine, corticosteroids, daunomycin, fluorouracil, heparin and retinoid s have been used in man and show an effect in different stages of the devel opment of PVR. In this survey the effect of each drug is described and the clinical studies are discussed. This survey shows that there are many drugs that in addition to surgery mig ht influence the natural course of clinical PVR during different stages. Ho wever, the only drug for which a significant reduction in the number of reo perations has been demonstrated in a randomized prospective trial is daunom ycin. Literature search by medline.