Rb. Thompson et Ps. Allen, Sources of variability in the response of coupled spins to the PRESS sequence and their potential impact on metabolite quantification, MAGN RES M, 41(6), 1999, pp. 1162-1169
Citations number
35
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Using a numerical method of solving the equation of motion of the density m
atrix, an evaluation is presented of the sources of the marked variability
in the response to the paint resolved spectroscopy (PRESS) pulse sequence o
f coupled proton spin systems. The consequences of an inappropriate 180 deg
rees pulse design and of the limitations on radiofrequency power are demons
trated for a weakly coupled example, lactate. The dominating role of strong
coupling, which is present in most brain metabolites, is demonstrated for
glutamate, in which 160 terms in the density operator were tracked to monit
or the gross changes in lineshape and signal intensity as a function of the
two echo times. The predictions of the numerical solutions were confirmed
by experiments on phantoms of aqueous metabolite solutions. (C) 1999 Wiley-
Liss, Inc.