Transmission of hepatitis C virus (HCV) within prisons has long been suspec
ted but has not been satisfactorily documented. We present four cases of HC
V infection occurring during periods of continuous imprisonment. Each subje
ct was HCV seronegative on entering prison and on repeat testing after 4-52
months in prison, but subsequently became seropositive. Two subjects gave
a history of injecting drug use, and the most likely means of infection in
the other two subjects were lacerations from barbers shears and lacerations
arising from physical assault. There is an urgent need for detailed study
of the incidence of HCV infection and the modes of transmission in prisons.