Osteoarthritis caused by Neocosmospora vasinfecta

We report the case of a patient who developed an ankle osteoarthritis due t o the Ascomycete Neocosmospora vasinfecta, following accidental multiple tr auma to his legs in whilst in Africa. Antifungal susceptibility testing was performed. Despite a low amphotericin P minimal inhibitory concentration, parenteral antifungal therapy failed and amputation was required to resolve the osteoarthritis. Possible reasons for the failure of this antifungal tr eatment are examined.