Hepatosplenic candidiasis after neutropenic phase of acute leukaemia

Hepatosplenic candidiasis following granulocytopenic periods is a relativel y recently recognised problem in immunocompromised patients, particularly i n those with acute leukaemia. We present three patients in whom diagnosis o f hepatosplenic candidiasis was suspected on the basis of ultrasonographic (US), computed tomographic (CT) findings and confirmed by laparoscopy and b iopsy of liver lesions. All three patients were successfully treated briefl y with amphotericin B, followed by a longer period of fluconazole. In one p atient laparotomy and surgical evacuation of abscesses was performed. This condition could be more often recognised by careful follow-up of liver func tion test, C-reactive protein level, ultrasonography, CT and MRI after reco very from chemotherapy-induced neutropenia.