Alcohol and genetics: new animal models

Citation
Ke. Browman et Jc. Crabbe, Alcohol and genetics: new animal models, MOL MED TOD, 5(7), 1999, pp. 310-318
Citations number
49
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
MOLECULAR MEDICINE TODAY
ISSN journal
13574310 → ACNP
Volume
5
Issue
7
Year of publication
1999
Pages
310 - 318
Database
ISI
SICI code
1357-4310(199907)5:7<310:AAGNAM>2.0.ZU;2-A
Abstract
In recent years, it has become increasingly evident that there is a genetic component to alcoholism. Attempts to isolate alcoholism genes have met wit h modest success, in part because alcoholism is a multigenic trait, Recentl y, experimental animal models and novel genetic manipulations have provided several clues as to the specific genes involved in alcoholism, and extensi ve research has identified many genes that might influence responses to alc ohol, Although not all of these might be proven to influence drug sensitivi ty, research has provided evidence for the involvement of a few genes. Ulti mately, findings from animal models that investigate the function of specif ic genes could aid the development of pharmacotherapies to treat alcohol de pendence.