Efficacy, safety and toleration of fluconazole suppositories in the treatment of oral candidosis

An open multicentre, noncomparative study was conducted in three countries to investigate the efficacy, safety and tolerance of fluconazole suppositor ies in the treatment of oropharyngeal candidosis. Patients received flucona zole 100 mg day(-1) in the form of suppositories or capsules. Minimum durat ion of total treatment was 7 days, maximum total treatment duration was 14 days, and median duration of total treatment was 9.5 (7-14) days. After hav ing received suppository-based treatment for at least 5 days, patients coul d be switched to oral treatment. Eighty-two male and 19 female patients wit h a mean age of 43 years were enrolled in the study. The median duration of suppository treatment was 8.9 (5-14) days. Patients were evaluated clinica lly and mycologically at regular intervals during and at the end of treatme nt. Seventy-nine of 101 patients enrolled in the study were considered effi cacy-evaluable. Clinical cure was achieved in 75 of 79 (95%) patients and i mprovement was seen in four of 79 (5%) at the end of therapy. At follow-up after 1 month, clinical cure was observed in 48 of 63 (76%) patients. The r esults of this study demonstrates that the fluconazole suppository formulat ion is effective, safe and well tolerated.