A patient was evaluated with familial trigeminal neuralgia (TN) and contral
ateral hemifacial spasm. The mother of the patient, 5 of 10 siblings, and 1
nephew also had TN confirmed by neurologists. The transmission of TN was s
uggestive of an autosomal dominant inheritance. This family provides additi
onal evidence of a genetic basis for TN in selected cases and also provokes
further speculation on a common unifying hypothesis of pathophysiology in
cranial rhizopathies.