Linkage of proximal myotonic myopathy to chromosome 3q

Authors
Ricker, K Grimm, T Koch, MC Schneider, C Kress, W Reimers, CD Schulte-Mattler, W Mueller-Myhsok, B Toyka, KV Mueller, CR
Citation
K. Ricker et al., Linkage of proximal myotonic myopathy to chromosome 3q, NEUROLOGY, 52(1), 1999, pp. 170-171
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
52
Issue
1
Year of publication
1999
Pages
170 - 171
Database
ISI
SICI code
0028-3878(19990101)52:1<170:LOPMMT>2.0.ZU;2-Y
Abstract
We performed genetic linkage analysis in nine German proximal myotonic myop athy (PROMM) families using DNA-markers D3S1541 and D3S1589 from the region of the recently discovered gene locus of myotonic dystrophy type 2 (DM2) o n chromosome 3q. Two-point analysis supplied an lod score of 5.9. We conclu de that a gene causing PROMM is located on chromosome 3q. PROMM and DM2 may be allelic disorders or may be caused by closely linked genes.