Diffusion-weighted MRI in sporadic Creutzfeldt-Jakob disease

Diffusion-weighted MRI (DWI) was used in three patients with autopsy-proven sporadic Creutzfeldt-Jakob disease (CJD) to provide a rapid noninvasive wa y to make this sometimes confusing diagnosis. DWI prompted the diagnosis of CJD at an early stage and appears to be particularly useful for monitoring the progression of the disease. We suggest that patients with suspected CJ D and no abnormalities on T2- and proton density-weighted images may have c ortical involvement on DWI.