Serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5HT(2) receptors

Authors
Lee, K Dixon, AK Pinnock, RD
Citation
K. Lee et al., Serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5HT(2) receptors, NEUROSCI L, 270(1), 1999, pp. 56-58
Citations number
14
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
270
Issue
1
Year of publication
1999
Pages
56 - 58
Database
ISI
SICI code
0304-3940(19990723)270:1<56:SDHIIT>2.0.ZU;2-4
Abstract
Patch-clamp recording techniques were used to examine the effect of seroton in (5HT) upon interneurones contained in the stratum oriens layer of hippoc ampal slices. Bath application of 1-20 mu M 5HT depolarized neurones by the induction of an inward current at -60 mV. This inward current was Na+-depe ndent in nature, was mimicked by the 5HT(2) receptor agonist 1 -(2,5-dimeth oxy-4-iodophenyl)-2-aminopropane (DOI) and was inhibited by pre-incubation with the 5HT2 receptor antagonist ritanserin. (C) 1999 Elsevier Science Ire land Ltd. All rights reserved.