A convenient approach to N-3 alkylation of 9-substituted guanines

Authors
Ostrowski, T Zeidler, J Goelizski, T Golankiewicz, B
Citation
T. Ostrowski et al., A convenient approach to N-3 alkylation of 9-substituted guanines, NUCLEOS NUC, 18(4-5), 1999, pp. 565-567
Citations number
4
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
565 - 567
Database
ISI
SICI code
0732-8311(1999)18:4-5<565:ACATNA>2.0.ZU;2-W
Abstract
Aryl or tert-butyl substituent in the 6 position of 3,9-dihydro-3-[(2-hydro xy-ethoxy)methyl]-9-oxo-6-R-5H-imid 1 directs the benzylation reaction part ly into N-4 position to give 3. Cleavage of the third ring of 3 gives 3-ben zylacycloguanosine 5, a first 3-aralkilo-9-substituted guanine.