Design and biological evaluation of new mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase

Authors
Wnuk, SF Yuan, CS Borchardt, RT Robins, MJ
Citation
Sf. Wnuk et al., Design and biological evaluation of new mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase, NUCLEOS NUC, 18(4-5), 1999, pp. 595-596
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
595 - 596
Database
ISI
SICI code
0732-8311(1999)18:4-5<595:DABEON>2.0.ZU;2-U
Abstract
Geminal dihalohomovinyl 2 and haloacetylenic 4 analogs derived from adenosi ne were prepared. These compounds exhibited type II (covalent) mechanism-ba sed inactivation of S-adenosyl-L-homocysteine hydrolase.