3 '-(N-hydroxyimino)-2 ',3-dideoxynucleosides and their derivatives: Synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues

Authors
Fedorov, I Kazmina, E Jasko, M Balzarini, J De Clercq, E Sommadossi, JP Imbach, JL Gosselin, G
Citation
I. Fedorov et al., 3 '-(N-hydroxyimino)-2 ',3-dideoxynucleosides and their derivatives: Synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues, NUCLEOS NUC, 18(4-5), 1999, pp. 633-634
Citations number
4
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
633 - 634
Database
ISI
SICI code
0732-8311(1999)18:4-5<633:3''ATD>2.0.ZU;2-Q
Abstract
A series of 3'-(N-hydroxyimino)-2',3'-dideoxynucleosides bearing different nucleic bases has been prepared. In vitro antiviral activity studies showed that among these compounds the thymine derivative possesses significant ac tivity against HIV, HSV, EBV and HBV. Conveniently 5'-protected 3'-(N-hydro xyimino)-2',3'-dideoxythymidine was further used as a synthon for the prepa ration of other nucleoside analogues.