Synthesis and biological activity of 4 '-thio-2 '-deoxy purine nucleosides

Authors
Messini, L Tiwari, KN Montgomery, JA Secrist, JA
Citation
L. Messini et al., Synthesis and biological activity of 4 '-thio-2 '-deoxy purine nucleosides, NUCLEOS NUC, 18(4-5), 1999, pp. 683-685
Citations number
3
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
4-5
Year of publication
1999
Pages
683 - 685
Database
ISI
SICI code
0732-8311(1999)18:4-5<683:SABAO4>2.0.ZU;2-E
Abstract
Coupling of 1-O-acetyl-2-deoxy-3,5-di-O-toluoyl-4-thio-D-ribofuranose with 6-chloropurine and 2,6-dichloropurine gave a mixture of 9 alpha and 9 beta anomers as major products. These anomers were separated and converted to 2' -deoxy-4'-thio analogues of adenosine, inosine, guanosine, 2-amino-adenosin e, and 2-chloro adenosine as well as their alpha-anomers.